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Ito-Kureha, T.* ; Heissmeyer, V.

Critical functions of N6-adenosine methylation of mRNAs in T cells.

Biochim. Biophys. Acta-Mol. Cell Res. 1870:119380 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The existence of N6-adenosine methylation (m6A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m6A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m6A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Epitranscriptomics ; M6a ; T Cell ; Tcr Signaling
ISSN (print) / ISBN 0167-4889
e-ISSN 1879-2596
Zeitschrift Biochimica et Biophysica Acta - Molecular Cell Research
Quellenangaben Band: 1870, Heft: 1, Seiten: , Artikelnummer: 119380 Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Abteilung für Molekulare Immunregulation (AMIR)
Förderungen Deutsche Forschungsgemeinschaft