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Streit, F.* ; Zillich, L.* ; Frank, J.* ; Kleineidam, L.* ; Wagner, M.* ; Baune, B.T.* ; Klinger-König, J.* ; Grabe, H.J.* ; Pabst, A.* ; Riedel-Heller, S.G.* ; Schmiedek, F.* ; Schmidt, B.* ; Erhardt, A.* ; Deckert, J.* ; NAKO Investigators (Peters, A.) ; Rietschel, M.* ; Berger, K.*

Lifetime and current depression in the German National Cohort (NAKO).

World J. Biol. Psychiatry, DOI: 10.1080/15622975.2021.2014152 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
OBJECTIVES: The present study introduces the assessment of depression and depressive symptoms in the German National Cohort (NAKO), a population-based mega cohort. Distribution of core measures, and associations with sociodemographic factors are examined. METHODS: The current analysis includes data from the first 101,667 participants (NAKO data freeze 100,000). Depression and depressive symptoms were assessed using a modified version of the depression section of the Mini-International Neuropsychiatric Interview (MINI), self-reported physician's diagnosis of depression, and the depression scale of the Patient Health Questionnaire (PHQ-9). RESULTS: A lifetime physician's diagnosis of depression was reported by 15.0% of participants. Of those, 47.6% reported having received treatment for depression within the last 12 months. Of the subset of 26,342 participants undergoing the full depression section of the modified MINI, 15.9% were classified by the MINI with a lifetime depressive episode. Based on the PHQ-9, 5.8% of the participants were classified as currently having a major or other depression by the diagnostic algorithm, and 7.8% according to the dimensional assessment (score ≥ 10). Increased frequency of depression measures and higher depression scores were observed in women and participants with lower education level or a family history of depression. CONCLUSIONS: The observed distributions of all depression measures and their associations with sociodemographic variables are consistent with the literature on depression. The NAKO represents a valuable epidemiologic resource to investigate depression, and the range of measures for lifetime and current depression allows users to select the most suitable instrument for their specific research question.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Mini Interview ; Phq-9 ; Phq-stress ; Depressive Symptoms ; Family History Of Depression
ISSN (print) / ISBN 1562-2975
e-ISSN 1814-1412
Zeitschrift The World Journal of Biological Psychiatry
Verlag Taylor & Francis
Verlagsort Abingdon
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)