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Meinhold, M.* ; Verbrugge, S.* ; Shi, A.* ; Schönfelder, M.* ; Becker, L. ; Jaspers, R.T.* ; Zammit, P.S.* ; Wackerhage, H.*

Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation.

Cell Tissue Res. 395, 271–283 (2024)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
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In skeletal muscle, the Hippo effector Yap promotes satellite cell, myoblast, and rhabdomyoblast proliferation but prevents myogenic differentiation into multinucleated muscle fibres. We previously noted that Yap drives expression of the first enzyme of the serine biosynthesis pathway, phosphoglycerate dehydrogenase (Phgdh). Here, we examined the regulation and function of Phgdh in satellite cells and myoblasts and found that Phgdh protein increased during satellite cell activation. Analysis of published data reveal that Phgdh mRNA in mouse tibialis anterior muscle was highly expressed at day 3 of regeneration after cardiotoxin injection, when markers of proliferation are also robustly expressed and in the first week of synergist-ablated muscle. Finally, siRNA-mediated knockdown of PHGDH significantly reduced myoblast numbers and the proliferation rate. Collectively, our data suggest that Phgdh is a proliferation-enhancing metabolic enzyme that is induced when quiescent satellite cells become activated.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Myoblast ; Phgdh ; Phosphoglycerate Dehydrogenase ; Skeletal Muscle ; Taz ; Yap; Skeletal-muscle; Gene-expression; Satellite Cells; 3-phosphoglycerate Dehydrogenase; Serine Synthesis; Hippo Pathway; Reveals; Yap; Metabolism; Drosophila
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0044-3794
e-ISSN 1432-0878
Zeitschrift Cell and Tissue Research
Quellenangaben Band: 395, Heft: , Seiten: 271–283 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500692-001
Förderungen Technische Universitt Mnchen (1025)
DOI 10.1007/s00441-023-03851-w
WOS ID 001137200200001
Scopus ID 85181440672
PubMed ID 38183459
Erfassungsdatum 2024-01-07
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