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Dai, E.* ; Chen, X.* ; Linkermann, A.* ; Jiang, X.* ; Kang, R.* ; Kagan, V.E.* ; Bayir, H.* ; Yang, W.S.* ; Garcia-Saez, A.J.* ; Ioannou, M.S.* ; Janowitz, T.* ; Ran, Q.* ; Gu, W.* ; Gan, B.* ; Krysko, D.V.* ; Zhu, X.* ; Wang, J.* ; Krautwald, S.* ; Toyokuni, S.* ; Xie, Y.* ; Greten, F.R.* ; Yi, Q.* ; Schick, J. ; Liu, J.* ; Gabrilovich, D.I.* ; Zeh, H.J.* ; Zhang, D.D.* ; Yang, M.* ; Iovanna, J.L.* ; Kopf, M.* ; Adolph, T.E.* ; Chi, J.T.* ; Li, C.* ; Ichijo, H.* ; Karin, M.* ; Sankaran, V.G.* ; Zou, W.* ; Galluzzi, L.* ; Bush, A.I.* ; Li, B.* ; Melino, G.* ; Baehrecke, E.H.* ; Lotze, M.T.* ; Klionsky, D.J.* ; Stockwell, B.R.* ; Kroemer, G.* ; Tang, D.*

A guideline on the molecular ecosystem regulating ferroptosis.

Nat. Cell Biol., DOI: 10.1038/s41556-024-01360-8 (2024)
DOI PMC
Open Access Green: Postprint online verfügbar 10/2024
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Cell-death; Lipid-peroxidation; Promotes Ferroptosis; Cancer-cells; Gpx4; Protects; Stress; Susceptibility; Activation; Roles
ISSN (print) / ISBN 1465-7392
e-ISSN 1476-4679
Zeitschrift Nature Cell Biology
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOXI)
Förderungen US National Institutes of Health