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Fertl, A.* ; Menzel, M.* ; Hofer, T.P. ; Morresi-Hauf, A.* ; Ziegler-Heitbrock, L. ; Frankenberger, M.

Monitoring of glucocorticoid therapy by assessment of CD14(+)CD16(+) monocytes: A case report.

Immunobiology 213, 909-916 (2008)
DOI
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Bronchiolitis obliterans with organizing pneumonia (BOOP) is a disease affecting small airways and alveoli. It is characterized by interstitial inflammation rich in foamy macrophages and by fibroblastic connective tissue expanding into the airway and alveolar lumen. We report herein on a 54-year-old male BOOP patient who was treated with glucocorticoids (GCs) and who over a 5-year period had three relapses. At diagnosis the patient showed elevated CD14(+)CD16(+) monocyte numbers (85cells/mul) and increased serum C-reactive protein (CRP) levels (29.4mg/l). With GC therapy both parameters decreased within a few days. Diagnosis of relapse was preceded by a rise in CD14(+)CD16(+) monocyte numbers and in CRP levels which again responded to GC treatment. We conclude that determination of CD14(+)CD16(+) monocytes is a useful marker for monitoring of BOOP diagnosis and GC therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter BOOP; Glucocorticoids; Monocyte subpopulations; CRP
ISSN (print) / ISBN 0171-2985
e-ISSN 1878-3279
Zeitschrift Immunobiology : Experimental and Clinical
Quellenangaben Band: 213, Heft: 9-10, Seiten: 909-916 Artikelnummer: , Supplement: ,
Verlag Urban & Fischer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)