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Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.
Nat. Neurosci. 27, 2292-2309 (2024)
Over the past decade, single-cell genomics technologies have allowed scalable profiling of cell-type-specific features, which has substantially increased our ability to study cellular diversity and transcriptional programs in heterogeneous tissues. Yet our understanding of mechanisms of gene regulation or the rules that govern interactions between cell types is still limited. The advent of new computational pipelines and technologies, such as single-cell epigenomics and spatially resolved transcriptomics, has created opportunities to explore two new axes of biological variation: cell-intrinsic regulation of cell states and expression programs and interactions between cells. Here, we summarize the most promising and robust technologies in these areas, discuss their strengths and limitations and discuss key computational approaches for analysis of these complex datasets. We highlight how data sharing and integration, documentation, visualization and benchmarking of results contribute to transparency, reproducibility, collaboration and democratization in neuroscience, and discuss needs and opportunities for future technology development and analysis.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
ISSN (print) / ISBN
1097-6256
e-ISSN
1546-1726
Zeitschrift
Nature Neuroscience
Quellenangaben
Band: 27,
Heft: 12,
Seiten: 2292-2309
Verlag
Nature Publishing Group
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Pioneer Campus (HPC)
Institute of Computational Biology (ICB)
Institute of Computational Biology (ICB)