PuSH - Publikationsserver des Helmholtz Zentrums München

Kullmann, S. ; Wagner, L. ; Hauffe, R.* ; Kühnel, A.* ; Sandforth, L. ; Veit, R. ; Dannecker, C. ; Machann, J. ; Fritsche, A. ; Stefan, N. ; Preissl, H. ; Kroemer, N.B.* ; Heni, M.* ; Kleinridders, A.* ; Birkenfeld, A.L.

A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

Nat. Metab. 7, 469-477 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Alzheimers-disease; Adipose-tissue; Reward; Sensitivity; Resistance; Inflammation; Version; Go
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Zeitschrift Nature metabolism
Quellenangaben Band: 7, Heft: 3, Seiten: 469-477 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Federal Ministry of Education and Research
Bundesministerium fr Bildung und Forschung (Federal Ministry of Education and Research)