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Hoffmann, G.V.* ; Gottschlich, A.* ; Subklewe, M.* ; Kobold, S.

Novel approaches to CAR T cell target identification in acute myeloid leukemia.

Curr. Opin. Pharmacol. 82:102524 (2025)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Identifying safe and effective CAR T cell targets in acute myeloid leukemia (AML) is challenging due to the disease's complexity and overlap with normal hematopoiesis. This review highlights advances in target discovery for AML, emphasizing innovative approaches. Structural surfaceomics identifies tumor-specific protein conformations, while AI-driven single-cell RNA sequencing integrates multi-source data to pinpoint optimal targets. Refined cell surface capture technology maps the AML surfaceome without relying on predefined antibodies. These strategies enhance CAR T cell specificity and minimize off-tumor effects, offering promising pathways for safer and more effective AML treatments and broader cancer therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Stem-cells; Antibody; Therapy; Heterogeneity; Expression; Ozogamicin; Cultures; Cancer
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Zeitschrift Current opinion in pharmacology
Quellenangaben Band: 82, Heft: , Seiten: , Artikelnummer: 102524 Supplement: ,
Verlag Elsevier
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Unit for Clinical Pharmacology (KKG-EKLiP)
Förderungen Bavarian Research Foundation (BAYCELLATOR)
Marie Sklodowska-Curie Training Network for Optimizing Adoptive T Cell Therapy of Cancer - Horizon 2020 programme of the European Union
German Cancer Aid
Wilhelm-Sander-Stiftung
Ernst Jung Stiftung
Institutional Strategy LMUexcellent of LMU Munich
Bavarian Ministry for Economical Affairs
Bundesministerium fur Bildung und Forschung
European Research Council
Deutsche Forschungsgemeinschaft (DFG)
Fritz-Bender Foundation
Monika-Kutzner Foundation for Cancer Research
Horizon 2020 programme of the European Union