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Deoxygenation trends and their multivariate association with self-reported fatigue in post-COVID syndrome.
Biomedicines 13, 1371 - 1371 (2025)
Background/Objectives: A relevant subgroup of post-COVID-19
syndrome (PCS) patients suffers from post-exertional malaise (PEM) and
cardiovascular or neurological symptoms, impairing daily functioning up
to becoming even house- or bedbound. Recent data suggest that PCS
summarizes different subgroups, one of them being characterized by an
impaired microcirculation. Thus, the aim of the present study was to
investigate local deoxygenation, measured with non-invasive
near-infrared regional spectroscopy (NIRS), and its association with
self-reported fatigue in patients with PCS compared to controls in light
exercise. Methods: 150 participants (100 PCS patients and 50
controls) were recruited. PEM was assessed using FACIT, Chalder, and
Bell scoring and Canadian Criteria. NIRS was used to measure local
oxygenation while kneading a stress ball and during recovery. Results:
PCS patients showed fatigue scores of 30 (Bell score), 20.6 (FACIT
fatigue score), and 9.914 (Chalder fatigue score). Decreased
deoxygenation peaks at the start of exercise were observed in patients
with PCS, compared to controls (p =
0.0002). Multivariate analysis identified a subgroup, showing an
association between strong fatigue and restricted oxygenation dynamics. Conclusions:
NIRS could be a potential tool to assess deoxygenation deficits even in
moderate to severely impaired PCS patients using light exercise
protocols.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Deoxygenation ; 2019-20 Coronavirus Outbreak ; Association (psychology)
ISSN (print) / ISBN
2227-9059
e-ISSN
2227-9059
Zeitschrift
Biomedicines
Quellenangaben
Band: 13,
Heft: 6,
Seiten: 1371 - 1371
Verlag
MDPI
Verlagsort
Basel, Switzerland
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
German Research Foundation
German Federal Ministry of Education and Research
Bavarian State Ministry of Health, Care and Prevention
German Federal Ministry of Education and Research
Bavarian State Ministry of Health, Care and Prevention