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Sieber-Schaefer, F.* ; Jiang, M.* ; Kromer, A.P.E.* ; Nguyen, A.* ; Molbay, M.* ; Pinto Carneiro, S.* ; Juergens, D.* ; Burgstaller, G. ; Popper, B.* ; Winkeljann, B.* ; Merkel, O.M.*

Machine learning-enabled polymer discovery for enhanced pulmonary siRNA delivery.

Adv. Func. Mat., DOI: 10.1002/adfm.202502805 (2025)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Nucleic acid therapeutics are poised to revolutionize the clinical treatment of diseases once considered undruggable. Although these therapeutic approaches hold significant promise, delivering the nucleic acid cargo remains challenging due to susceptibility to nuclease degradation. Among all carrier systems, polymers stand out for their high tunability and cost-effectiveness. However, their flexible structure greatly expands the chemical space, making experimental exploration both costly and time-consuming. Leveraging published data and machine learning methods provides a valuable strategy to address these issues. The present study demonstrates a way to merge data from multiple sources and uses this information to identify new polyesters that effectively deliver siRNA into lung cells. One newly discovered polymer is further examined in ex vivo experiments and tested in a mouse model. The results indicate that a polymer capable of silencing specific genes in vivo can be discovered through machine learning, circumventing an extensive trial-and-error process in the search for novel materials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter machine learning; poly(beta)aminoester; polyester; polymer discovery; polymeric nanoparticle; pulmonary delivery; siRNA delivery; Lung; Nanoparticles; Polyethylenimine; Release; Disease; Cells
ISSN (print) / ISBN 1616-301X
e-ISSN 1616-3028
Zeitschrift Advanced functional materials
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Förderungen China Scholarship Council