PuSH - Publikationsserver des Helmholtz Zentrums München: Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: A cohort study.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Urbano, T.* ; Michalke, B. ; Chiari, A.* ; Malagoli, C.* ; Bedin, R.* ; Tondelli, M.* ; Vinceti, M.* ; Filippini, T.*

Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: A cohort study.

Neurotoxicol. 110, DOI: 10.1016/j.neuro.2025.06.006 (2025)

Verlagsversion

Forschungsdaten

DOI

PMC

	Open Access Hybrid

Abstract
Metriken
Zusatzinfos

BACKGROUND: Iron dysregulation has been implicated in the pathogenesis of dementia, since it is an essential nutrient for neuronal function, but also contributes to oxidative stress and neurotoxicity at elevated levels. METHODS: We enrolled 56 individuals with newly-diagnosed mild cognitive impairment (MCI) and followed over a 47-month period to monitor conversion to dementia according to baseline percentage concentrations of cerebrospinal fluid iron species RESULTS: In this cohort, 28 participants developed Alzheimer's dementia, 5 frontotemporal dementia, 2 Lewy body dementia, and 2 vascular dementia during the follow-up. Higher Fe-Ferritin was associated with a higher though statistically unstable dementia risk (hazard ratio HR 1.36 for 10-unit % increase, 95% confidence interval-CI 0.88-2.11), while Fe-Transferrin was linked to a lower risk (HR 0.65, 95% CI 0.21-2.08) and inorganic Fe showed little association (HR 1.06, 95% CI 0.80-1.40). Patterns of association were non-linear: inorganic Fe had a U-shaped association, with reduced risk at 25-40% and increased risk above 45%; Fe-Ferritin showed an inverted U-shape relation with higher risk between 10-20%; Fe-Transferrin showed almost no relation with dementia risk. When considering conversion to Alzheimer's dementia only, the relation was similarly U-shaped for inorganic Fe and almost null for Fe-Transferrin, while Fe-Ferritin showed a positive relation with risk above 15%. CONCLUSIONS: Despite the statistical imprecision of the estimates, our study provides novel evidence linking iron species in cerebrospinal fluid to dementia risk in individuals with MCI. These findings also underscore the importance of elemental speciation in dementia research.

Impact Factor

Scopus SNIP

Altmetric

0.000