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Wittig, T. ; Winther, B. ; Reichl, C.* ; Schmidt, A.* ; Scheinert, D.* ; Steiner, S.

Optoacoustic imaging in lower extremity revascularization: A novel technique to assess perioperative muscle perfusion.

Photoacoustics 45:100756 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
OBJECTIVES: This proof-of-concept study aimed to assess the feasibility of Multispectral Optoacoustic Tomography (MSOT) in evaluating changes in oxygenated hemoglobin (HbO2) levels in muscles of the lower limb before and after lower extremity revascularization (LER). METHODS: In 26 patients, HbO2 levels were assessed before and after LER, with follow-up assessing symptom control and patency for up to six months. RESULTS: A significant difference in HbO2 levels was observed between pre- and post-LER in the muscles of the lower limb. In 10 patients, HbO2 levels did not increase following LER, and at the 6-month follow-up, 2 of these patients required target lesion revascularization (TLR) due to restenosis of ≥ 50 % stenosis. In contrast, 16 patients demonstrated increased HbO2 levels post-LER, with no patients requiring TLR at 6-months. CONCLUSION: This study demonstrates the potential of MSOT to detect changes in tissue perfusion following LER, highlighting its promise as a novel imaging modality for guiding treatment strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Lower Extremity Revascularization ; Multispectral Optoacoustic Tomography ; Muscle Perfusion ; Optoacoustic ; Peripheral Artery Disease; Outcomes; Disease
ISSN (print) / ISBN 2213-5979
Zeitschrift Photoacoustics
Quellenangaben Band: 45, Heft: , Seiten: , Artikelnummer: 100756 Supplement: ,
Verlag Elsevier
Verlagsort Hackerbrucke 6, 80335 Munich, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)