PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ehrlich, S.* ; Licht, L.* ; Kolb, T.* ; Hoffmann, C.* ; Stender, E.* ; Tam, F.I.* ; Poitz, D.M.* ; Roessner, V.* ; Bornstein, S.R. ; Perakakis, N.

Impact of acute anorexia nervosa and of short-/long-term recovery after refeeding on the hormonal profiles of activin A, GDF-15 and follistatins.

Mol. Psychiatry, DOI: 10.1038/s41380-025-03245-0 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Anorexia Nervosa (AN) is a severe eating disorder characterized by endocrine and metabolic abnormalities. In this study, we evaluated how the concentrations of proteins recently linked with energy homeostasis might be altered in acute AN (acAN), whether their levels are associated with reproductive hormones and whether they are restored after weight recovery. Our results show that activin A, follistatin, LH and estradiol concentrations are decreased while growth/differentiation factor-15 (GDF-15) concentrations are increased in 79 females with acAN before weight restoration (acAN_T1) compared to 79 healthy control females not receiving oral contraception (HC_OCP-). The concentrations of all hormones were partially or completely restored after weight restoration by short-term refeeding (acAN_T2) and in 35 females after long-term ( >6 months) recovery from AN not receiving OCPs (recAN_OCP-). Low activin A and high GDF-15 concentrations, as in acAN_T1, were also observed in 45 healthy control females under OCP (HC_OCP+) compared to HC_OCP-. Follistatin levels were ~3-fold higher in HC_OCP+ and recAN_OCP+ (45 female recAN under OCP) compared to HC_OCP- or recAN_OCP- respectively. LH, FSH and estradiol concentrations were positively associated with activin A and negatively with GDF-15 and follistatin. In conclusion, we report profound alterations in GDF-15, activin A and follistatin concentrations in acAN, which are associated with the concentrations of reproductive hormones and they are regulated by OCP and weight recovery by refeeding. Our findings support the evaluation of strategies targeting these hormones (e.g. GDF-15 inhibition) in AN to potentially increase body weight and thereby facilitate the resumption of reproductive function.
Impact Factor
Scopus SNIP
Altmetric
10.100
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Eating-disorder; Leptin; Women; Outcomes
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1359-4184
e-ISSN 1476-5578
Zeitschrift Molecular Psychiatry
Verlag Nature Publishing Group
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-012
G-502600-007
Förderungen Deutsche Forschungsgemeinschaft (German Research Foundation)
DOI 10.1038/s41380-025-03245-0
WOS ID 001575201600001
Scopus ID 105016534925
PubMed ID 40968258
Erfassungsdatum 2025-10-21
[➜Korrektur melden]