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Accelerometry-assessed sleep and liver health in adolescents and adults: Links to liver enzymes, MASLD, and MRI-derived liver fat.
Sleep Med. 138:108686 (2025)
Verlagsversion
Forschungsdaten
DOI
PMC
BACKGROUND: To investigate associations of accelerometry-assessed sleep characteristics with liver enzymes and liver fat in adolescents and adults. METHODS: We analyzed data from four German cohorts: GINIplus and LISA (n = 1132, 14-16 years), KORA-Fit (n = 1318, 53-74 years), and KORA-MRI (n = 108, 48-67 years). Eleven accelerometry-assessed sleep characteristics captured sleep quantity, efficiency, fragmentation, latency, and timing. Liver enzymes included alanine aminotransferase (ALT), aspartate aminotransferase, and gamma-glutamyl transferase (GGT). Adult liver fat markers were steatotic liver disease (SLD) and metabolic dysfunction-associated SLD (MASLD, plus ≥1 cardiometabolic risk factor and without excessive alcohol intake), defined by fatty liver index (FLI, ≥60) or 3T-Magnetic Resonance Imaging (MRI) derived proton density fat fraction (PDFF, ≥5 %). Linear and logistic regression models were evaluated. RESULTS: Time awake per hour after sleep onset (WASO/h) was associated with higher ALT both in adolescents (percentage change [95 % confidence interval, CI] per interquartile range [IQR]: 3.82 [0.86, 6.87]) and adults (3.05 [0.38, 5.78]). In adults, WASO/h was associated with increased odds of SLD-FLI (odds ratio [95 %CI] per IQR: 1.47 [1.26, 1.71]), MASLD-FLI (1.61 [1.34, 1.94]), SLD-PDFF (2.10 [1.16, 3.78]), and MASLD-PDFF (3.32 [1.47, 7.52]). Similar results were observed for poor sleep efficiency and sleep fragmentation index. However, these associations lost significance after body mass index (BMI) adjustment. Significant interactions between WASO/h and BMI groups were observed for ALT, GGT, and SLD-FLI. CONCLUSIONS: Objectively measured sleep fragmentation was associated with increased liver enzymes in adolescents and hepatic steatosis in adults, with BMI potentially mediating or modifying these associations.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Accelerometry ; Liver Enzymes ; Mri ; Metabolic Dysfunction-associated Steatotic Liver Disease ; Obesity ; Sleep Fragmentation; Wake Identification; Association; Apnea; Population; Quality; Markers
ISSN (print) / ISBN
1389-9457
e-ISSN
1878-5506
Zeitschrift
Sleep Medicine
Quellenangaben
Band: 138,
Artikelnummer: 108686
Verlag
Elsevier
Verlagsort
Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)
Förderungen
European Research Council (ERC) under the European Union
Federal Ministry for Environment
Commission of the European Communities
Helmholtz Zentrum Mnchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
University Hospital of Augsburg
German Research Foundation
Centre for Diabetes Research (DZD e. V., Neuherberg, Germany)
Siemens Healthcare
scholarship under the State Scholarship Fund by the China Scholarship Council
Research Institute at Marien-Hospital Wesel
Federal Ministry for Environment
Commission of the European Communities
Helmholtz Zentrum Mnchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
University Hospital of Augsburg
German Research Foundation
Centre for Diabetes Research (DZD e. V., Neuherberg, Germany)
Siemens Healthcare
scholarship under the State Scholarship Fund by the China Scholarship Council
Research Institute at Marien-Hospital Wesel