Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
Verlagsversion
Forschungsdaten
DOI
PMC
 |
Open Access Hybrid |
|
möglich sobald bei der ZB eingereicht worden ist.
Associations between early-life exposures and the infant skin microbiome.
Br. J. Dermatol.:ljaf524 (2026)
Verlagsversion
Forschungsdaten
DOI
PMC
BACKGROUND: Factors influencing the early-life skin microbiome, and the association with atopic dermatitis (AD), are relatively unexplored. OBJECTIVE: To evaluate associations with the infant skin microbiome during the first year of life. METHODS: 3-month-old infants from the Enquiring About Tolerance (EAT) birth cohort were examined for AD at enrolment, 1 and 3 years of age. Parent-completed questionnaires, trans-epidermal water loss (TEWL), and filaggrin mutation status were evaluated. Bacterial swabs were collected from the elbow crease and volar forearm in 148 infants at 3 months and 1 year of age, and the microbiome composition was characterized using 16S rRNA gene sequencing (V3-V4 region). RESULTS: Shannon diversity was significantly higher at the forearm compared to the elbow. Staphylococcus, Acinetobacter, and Streptococcus were the most abundant genera across time and body-site. Microbiome community composition was primarily associated with body-site and age (p≤0.001, both). Other significant associations were found with ethnicity (p=0.009), filaggrin status (p≤0.001), urban-vs-rural residence (p=0.005), older siblings (p=0.041), bath product usage at 3 months (p=0.011), but not with pets (p=0.159), systemic antibiotics (p=0.27) nor with bathing frequency (p=0.109). The microbiome was associated with elevated TEWL (3-months p=0.004, 1-year p≤0.001) and with concurrent AD (3-months p=0.027, 1-year p≤0.001). Streptococcus parasanguinis was significantly less abundant in non-lesional skin of infants with AD at 3 months. CONCLUSION: In addition to age and body-site, the infant skin microbiome is associated with heritable factors, the home environment, hygiene practices, and with the presence of AD.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Atopic-dermatitis; Colonization; Diversity; Severity; Mode; Risk
ISSN (print) / ISBN
0007-0963
e-ISSN
1365-2133
Zeitschrift
British Journal of Dermatology - BJD
Quellenangaben
Artikelnummer: ljaf524
Verlag
Wiley
Verlagsort
Great Clarendon St, Oxford Ox2 6dp, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Environmental Medicine (IEM)
Förderungen
UK Food Standards Agency
MC_G1001205
NIHRCS/01/2008/009
a Clinician Scientist Award from the UK National Institute for Health Research
T07051
European Federation of Pharmaceutical Industries and Associations
MC_G1001205
NIHRCS/01/2008/009
a Clinician Scientist Award from the UK National Institute for Health Research
T07051
European Federation of Pharmaceutical Industries and Associations