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Open Access Green as soon as Postprint is submitted to ZB.
T1 Relaxation Time at 0.2 Tesla for Monitoring Regional Hyperthermia : Feasibility Study in Muscle and Adipose Tissue.
Magn. Reson. Med. 47, 1194-1201 (2002)
The purpose of this study was to characterize T-1, particularly in the hyperthermia temperature range (ca. 37-44degreesC), in order to control regional hyperthermia with MR monitoring using 0.2 Tesla, and to improve T-1 mapping. A single-slice and a new multislice T One by Multiple Read-Out Pulses" (TOMROP) pulse sequence were used for fast ill mapping in a clinical MRI hyperthermia hybrid system. Temporal stability, temperature sensitivity, and reversibility of T-1 were investigated in a polyamidacryl gel phantom and in samples of muscle and adipose tissues from turkey and pig, and verified in patients. In the gel phantom a high linear correlation between T-1 and temperature (R-2 = 0.97) was observed. In muscle and adipose tissue, T-1 and temperature had a linear relationship below a breakpoint of 43degreesC. Above this breakpoint muscle tissue showed irreversible tissue changes; these effects were not visible in adipose tissue. The ex vivo results were confirmed in vivo under clinical conditions. T-1, mapping allows the characterization of hyperthermia-related tissue response in healthy tissue. T-1, in combination with fast mapping, is suitable for controlling regional hyperthermia at 0.2 T within the hybrid system."
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
MRI; MR thermometry; hyperthermia; T 1 mapping; thermal therapy
ISSN (print) / ISBN
0740-3194
e-ISSN
1522-2594
Journal
Magnetic Resonance in Medicine
Quellenangaben
Volume: 47,
Pages: 1194-1201
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)