Response to Neoadjuvant Chemotherapy Combined with Regional Hyperthermia Predicts Long-Term Survival for Adult Patients with Retroperitoneal and Visceral High-Risk Soft Tissue Sarcomas.
Purpose: To determine the efficacy of neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for local tumor control and overall survival (OS) in adult patients with retroperitoneal or visceral (RP/V) high-risk soft tissue sarcomas (HR-STS).Patients and Methods: From 1991 to 1997, 58 patients with HR-STS at RP/V sites were prospectively treated with four cycles of etoposide, ifosfamide, and doxorubicin combined with RHT followed by surgery, adjuvant chemotherapy, and radiation.