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Takamatsu, H.* ; Takegahara, N.* ; Nakagawa, Y.* ; Tomura, M.* ; Taniguchi, M.* ; Friedel, R.H. ; Rayburn, H.* ; Tessier-Lavigne, M.* ; Yoshida, Y.* ; Okuno, T.* ; Mizui, M.* ; Kang, S.* ; Nojima, S.* ; Tsujimura, T.* ; Nakatsuji, Y.* ; Katayama, I.* ; Toyofuku, T.* ; Kikutani, H.* ; Kumanogoh, A.*

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.

Nat. Immunol. 11, 594-560 (2010)
DOI PMC
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Leukocyte migration; Langerhans cells; Nodes; Plexin-A1; Integrin; Roles; Actin; Skin; Morphogenesis; Regeptiors
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 11, Issue: 7, Pages: 594-560 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)