PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Takamatsu, H.* ; Takegahara, N.* ; Nakagawa, Y.* ; Tomura, M.* ; Taniguchi, M.* ; Friedel, R.H. ; Rayburn, H.* ; Tessier-Lavigne, M.* ; Yoshida, Y.* ; Okuno, T.* ; Mizui, M.* ; Kang, S.* ; Nojima, S.* ; Tsujimura, T.* ; Nakatsuji, Y.* ; Katayama, I.* ; Toyofuku, T.* ; Kikutani, H.* ; Kumanogoh, A.*

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.

Nat. Immunol. 11, 594-560 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.460
4.460
74
151
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Leukocyte migration; Langerhans cells; Nodes; Plexin-A1; Integrin; Roles; Actin; Skin; Morphogenesis; Regeptiors
Language
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 11, Issue: 7, Pages: 594-560 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
DOI 10.1038/ni.1885
Scopus ID 77953808714
PubMed ID 20512151
Erfassungsdatum 2010-09-08
[➜Report correction]