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Open Access Green as soon as Postprint is submitted to ZB.
HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals.
Eur. J. Neurosci. 17, 2084-2096 (2003)
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four HCN channel isoforms (HCN1–4) are expressed differentially in the retina. In particular, different classes of bipolar cells have a different inventory of HCN channels. We found no evidence for the formation of heterooligomeric HCN channels. HCN channels are densely clustered at synaptic terminals of bipolar cells and photoreceptors. This suggests that HCN channels are involved in the control of transmitter release.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
bipolar cell; electrophysiology; HCN channels; Ih; immunocytochemistry; retina
ISSN (print) / ISBN
0953-816X
e-ISSN
1460-9568
Journal
European Journal of Neuroscience
Quellenangaben
Volume: 17,
Issue: 10,
Pages: 2084-2096
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)