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Open Access Green as soon as Postprint is submitted to ZB.
Endocrine effects of sublethal exposure to persistent organic pollutants (POPs) on silver carp ( Hypophthalmichthys molitrix).
Environ. Pollut. 120, 683-690 (2002)
Silver carp (Hypophthalmichthys molitrix) samples were collected from five selected sites that represent diverse levels of downgraded persistent organic pollutants (POPs) contamination in Ya-Er Lake in October 1999. Hepatic ethoxyresorufin-O-deethylase (EROD) and UDP glucuronosyltransferase (UDPGT) activities, hepatosomatic index (HSI), hepatic retinoids, serum thyroid hormones were measured. It was found that hepatic retinol and serum free 3,5,3′- tetraiodothyronine (FT3) significantly increased (P<0.01) when both hepatic EROD and UDPGT activities significantly declined (P<0.01) from pond 1 to 5 with decrease in the degree of pollution. This significant negative correlation (P<0.01) suggests that the persistent organochlorinated contaminants could induce hepatic EROD and UDPGT activities, alter retinoid and thyroid hormone homeostasis, and finally lead to the reduction of retinol and FT3, the two biologically active forms of retinoids and thyroid hormone in silver carp of Ya-Er Lake.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
POPs; EROD; UDPGT; Retinoids; Thyroid hormone; Silver carp
ISSN (print) / ISBN
0269-7491
e-ISSN
1873-6424
Journal
Environmental Pollution
Quellenangaben
Volume: 120,
Issue: 3,
Pages: 683-690
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)