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Newton-Cheh, C.* ; Johnson, T.* ; Gateva, V.* ; Tobin, M.D.* ; Bochud, M.* ; Coin, L.* ; Najjar, S.S.* ; Zhao, J.H.* ; Heath, S.C.* ; Eyheramendy, S. ; Papadakis, K.* ; Voight, B.F.* ; Scott, L.J.* ; Zhang, F.* ; Farrall, M.* ; Tanaka, T.* ; Wallace, C.* ; Chambers, J.C.* ; Khaw, K.T.* ; Nilsson, P.* ; van der Harst, P.* ; Polidoro, S.* ; Grobbee, D.E.* ; Onland-Moret, N.C.* ; Bots, M.L.* ; Wain, L.V.* ; Elliott, K.S.* ; Teumer, A.* ; Luan, J.* ; Lucas, G.* ; Kuusisto, J.* ; Burton, P.R* ; Hadley, D.* ; McArdle, W.L.* ; Brown, M.* ; Dominiczak, A.* ; Newhouse, S.J.* ; Samani, N.J.* ; Webster, J.* ; Zeggini, E.* ; Beckmann, J.S.* ; Bergmann, S.* ; Lim, N.* ; Song, K.* ; Vollenweider, P.* ; Waeber, G.* ; Waterworth, D.M.* ; Yuan, X.* ; Groop, L.* ; Orho-Melander, M.* ; Allione, A.* ; di Gregorio, A.* ; Guarrera, S.* ; Panico, S.* ; Ricceri, F.* ; Romanazzi, V.* ; Sacerdote, C.* ; Vineis, P.* ; Barroso, I.* ; Sandhu, M.S.* ; Luben, R.N.* ; Crawford, G.J.* ; Jousilahti, P.* ; Perola, M.* ; Boehnke, M.* ; Bonnycastle, L.L.* ; Collins, F.S.* ; Jackson, A.U.* ; Mohlke, K.L.* ; Stringham, H.M.* ; Valle, T.T.* ; Willer, C.J.* ; Bergman, R.N.* ; Morken, M.A.* ; Döring, A. ; Gieger, C. ; Illig, T. ; Meitinger, T. ; Org, E.* ; Pfeufer, A. ; Wichmann, H.-E. ; Kathiresan, S.* ; Marrugat, J.* ; O'Donnell, C.J.* ; Schwartz, .S.M.* ; Siscovick, D.S.* ; Subirana, I.* ; Freimer, N.B.* ; Hartikainen, A.L.* ; McCarthy, M.I.* ; O'Reilly, P.F.* ; Peltonen, L.* ; Pouta, A.* ; de Jong, P.E.* ; Snieder, H.* ; van Gilst, W.H.* ; Clarke, R.* ; Goel, A.* ; Hamsten, A.* ; Peden, J.F.* ; Seedorf, U.* ; Syvanen, A.C.* ; Tognoni, G.* ; Lakatta, E.G.* ; Sanna, S.* ; Scheet, P.* ; Schlessinger, D.* ; Scuteri, A.* ; Dörr, M.* ; Ernst, F.* ; Felix, S.B.* ; Homuth, G.* ; Lorbeer, R.* ; Reffelmann, T.* ; Rettig, R.* ; Völker, U.* ; Galan, P.* ; Gut, I.G.* ; Hercberg, S.* ; Lathrop, G.M.* ; Zelenika, D.* ; Deloukas, P.* ; Soranzo, N.* ; Williams, F.M.* ; Zhai, G.* ; Salomaa, V.* ; Laakso, M.* ; Elosua, R.* ; Forouhi, N.G.* ; Völzke, H.* ; Uiterwaal, C.S.* ; van der Schouw, Y.T.* ; Numans, M.E.* ; Matullo, G.* ; Navis, G.* ; Berglund, G.* ; Bingham, S.A.* ; Kooner, J.S.* ; Connell, J.M.* ; Bandinelli, S.* ; Ferrucci, L.* ; Watkins, H.* ; Spector, T.D.* ; Tuomilehto, J.* ; Altshuler, D.* ; Strachan, D.P.* ; Laan, M.* ; Meneton, P.* ; Wareham, N.J.* ; Uda, M.* ; Jarvelin, M.R.* ; Mooser, V.* ; Melander, O.* ; Loos, R.J.F.* ; Elliott, P.* ; Abecasis, G.R.* ; Caulfield, M.* ; Munroe, P.B.*

Genome-wide association study identifies eight loci associated with blood pressure.

Nat. Genet. 41, 666-676 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords methylenetetrahydrofolate reductase gene; low-renin hypertension; common variants; cell-differentiation; bartters-syndrome; public-health; risk; polymorphism; population; mutations
Language
Publication Year 2009
HGF-reported in Year 2009
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 6, Pages: 666-676 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
G-503900-004
DOI 10.1038/ng.361
Scopus ID 67349085063
PubMed ID 19430483
Erfassungsdatum 2009-12-03
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