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Age-related Reference Values for Serum Selenium Concentrations in Infants and Children.
Clin. Chem. 48, 555-560 (2002)
Background: Children are at particular risk for selenium deficiency, which has potentially serious medical implications. Reliable age-specific reference values for serum selenium concentrations in children are sparse, but are essential for the identification of selenium deficiency and decisions regarding selenium supplementation.Methods: Using electrothermal atomic absorption spectrometry we analyzed serum selenium concentrations from 1010 apparently healthy children (age range, 1 day to IS years) and from 60 patients on a protein-restricted diet because of inborn errors of metabolism. Reference intervals were defined according to recommended guidelines.Results: Medians for serum selenium concentrations showed a statistically significant age dependency: a decrease from the age <1 month (0.64 mumol/L) to 4 months (0.44 mumol/L); an increase to 0.62 mumol/L in the 4-12 months age group; constant values in children between I and 5 years of age (0.90 mumol/L); and an additional slight increase to reach a plateau between 5 and IS years (0.99 mumol/L). Of 43 children older than 1 year and on a protein-restricted diet, 87% showed serum selenium concentrations below the 2.5 percentile.Conclusions: Because of nutritional changes, serum selenium concentrations are significantly higher in older children than in infants under 1 year of age. The application of age-adjusted reference values may provide more specific criteria for selenium supplementation. Long-term protein restriction in children is reflected by a failure to achieve higher serum selenium concentrations with increasing age.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Children; selenium deficiency; age-specific reference values; electrothermal atomic absorption spectrometry
Language
english
Publication Year
2002
HGF-reported in Year
0
ISSN (print) / ISBN
0009-9147
e-ISSN
1530-8561
Journal
Clinical Chemistry
Quellenangaben
Volume: 48,
Pages: 555-560
Publisher
American Association for Clinical Chemistry
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)
PSP Element(s)
G-505100-005
Erfassungsdatum
2002-08-05