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Schramm, K.-W. ; Klimm, C. ; Hofmaier, A.* ; Kettrup, A.

Comparison of dioxin-like-response in vitro and chemical analysis of emissions and materials.

Chemosphere 42, 551-557 (2001)

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Samples from industrial and domestic emissions and materials were investigated by using in vitro assays for dioxin-like-response (DLR) and chemical analysis. The results show a small part of persistent bioaccumulative toxicants (PBT) to be responsive in vitro. Clean-up procedures directed to persistence decrease the amount of inducing toxicants substantially. The comparison of biological in vitro (B) and chemical (A) analysis show ratios between B and A below 10 for DLR of persistent inductors. The consideration of PAH improved the knowledge about unknown less persistent agonists.

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