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Lohrer, H.D.* ; Hieber, L. ; Zitzelsberger, H.

Differential mutation frequency in mitochondrial DNA from thyroid tumours.

Carcinogenesis 23, 1577-1587 (2002)
Open Access Green as soon as Postprint is submitted to ZB.
Lack of a chromatin structure and histone protection makes mitochondrial DNA susceptible to oxidative damage. Suboptimal DNA repair leads to a higher frequency of mitochondrial mutations, which are associated with aging, carcinogenesis and environmental insult. The instability of the hypervariable region 11 of the mitochondrial genome was investigated in radiation-associated thyroid tumours, which were diagnosed in children from Belarus after the accident at the Chernobyl nuclear power plant, and from 40 sporadic thyroid tumours from Munich. Two mutations were identified in two out of 126 tumours from Belarus, and eight mutations were found in six out of 40 tumours from Munich. All mutations were deletions or insertions of C in a poly-cytidine (C7TC6) microsatellite. The mutation frequency correlated with the age of the patients at surgery. Mutations with the typical pattern of base substitutions following oxidative DNA damage were not identified.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords mitochondria DNA; mtDNA; MSI
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Journal Carcinogenesis
Quellenangaben Volume: 23, Issue: 10, Pages: 1577-1587 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Radiation Biology (IMS)
Institute of Pathology (PATH)