PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Lohrer, H.D.* ; Hieber, L. ; Zitzelsberger, H.

Differential mutation frequency in mitochondrial DNA from thyroid tumours.

Carcinogenesis 23, 1577-1587 (2002)
Publ. Version/Full Text
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Lack of a chromatin structure and histone protection makes mitochondrial DNA susceptible to oxidative damage. Suboptimal DNA repair leads to a higher frequency of mitochondrial mutations, which are associated with aging, carcinogenesis and environmental insult. The instability of the hypervariable region 11 of the mitochondrial genome was investigated in radiation-associated thyroid tumours, which were diagnosed in children from Belarus after the accident at the Chernobyl nuclear power plant, and from 40 sporadic thyroid tumours from Munich. Two mutations were identified in two out of 126 tumours from Belarus, and eight mutations were found in six out of 40 tumours from Munich. All mutations were deletions or insertions of C in a poly-cytidine (C7TC6) microsatellite. The mutation frequency correlated with the age of the patients at surgery. Mutations with the typical pattern of base substitutions following oxidative DNA damage were not identified.
Impact Factor
Scopus SNIP
4.543
0.000
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords mitochondria DNA; mtDNA; MSI
Language english
Publication Year 2002
HGF-reported in Year 2002
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Journal Carcinogenesis
Quellenangaben Volume: 23, Issue: 10, Pages: 1577-1587 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Radiation Biology (IMS)
Institute of Pathology (PATH)
POF-Topic(s)
Research field(s)
Enabling and Novel Technologies
PSP Element(s) FE 70431
Scopus ID 0036799079
Erfassungsdatum 2002-10-28
[➜Report correction]