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Hoeschen, C. ; Mattsson, S.* ; Cantone, M.C.* ; Mikuz, M.* ; Lacasta, C.* ; Ebel, G.* ; Clinthorne, N.* ; Giussani, A.

Minimizing activity and dose with enhanced image quality by radiopharmaceutical administrations.

Radiat. Prot. Dosim. 139, 250-253 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are administered to the patient, meaning not only a radiation exposure to the diseased tissue but also to the healthy tissues of large parts of the body. 'Minimizing Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations' (MADEIRA) is a project cofunded by the European Commission within the Seventh Euratom Framework Programme that aims to improve three-dimensional (3D) nuclear medical imaging technologies significantly. MADEIRA is aiming to improve the efficacy and safety of 3D PET and SPECT functional imaging by optimising the spatial resolution and the signal-to-noise ratio, improving the knowledge of the temporal variation of the radiopharmaceuticals' uptake in and clearance from tumourous and healthy tissues, and evaluation of the corresponding patient dose. Using an optimised imaging procedure that improves the information gained per unit administered dose, MADEIRA aims especially to reduce the dose to healthy tissues of the patient. In this paper, an overall summary of the current achievements will be presented.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Algorithms; Body Burden*; Computer Simulation; Dose-Response Relationship; Radiation; Humans; Image Enhancement/methods*; Image Interpretation; Computer-Assisted/methods; Models; Biological; Radiation Dosage*; Radiation Protection/methods; Radiometry/methods*; Radiopharmaceuticals/administration & dosage; Radiopharmaceuticals/analysis*; Radiopharmaceuticals/diagnostic use*; Reproducibility of Results; Sensitivity and Specificity; Tomography; Emission-Computed/methods*
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Journal Radiation Protection Dosimetry
Quellenangaben Volume: 139, Issue: 1-3, Pages: 250-253 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Research Unit Medical Radiation Physics and Diagnostics (AMSD)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-503600-002
G-503600-001
DOI 10.1093/rpd/ncq104
Scopus ID 77953338210
PubMed ID 20228050
Erfassungsdatum 2010-07-28
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