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Dehghan, A.* ; Yang, Q.* ; Peters, A. ; Basu, S.* ; Bis, J.C.* ; Rudnicka, A.R.* ; Kavousi, M.* ; Chen, M.-H.* ; Baumert, J.J. ; Lowe, G.D.O.* ; McKnight, B.* ; Tang, W.* ; de Maat, M.* ; Larson, M.G.* ; Eyhermendy, S.* ; McArdle, W.L.* ; Lumley, T.* ; Pankow, J.S.* ; Hofman, A.* ; Massaro, J.M.* ; Rivadeneira, F.* ; Kolz, M. ; Taylor, K.D.* ; van Duijn, C.M.* ; Kathiresan, S.* ; Illig, T. ; Aulchenko, Y.S.* ; Volcik, K.A.* ; Johnson, A.D.* ; Uitterlinden, A.G.* ; Tofler, G.H.* ; Gieger, C. ; Psaty, B.M.* ; Couper, D.J.* ; Boerwinkle, E.* ; Koenig, W.* ; O'Donnell, C.J.* ; Witteman, J.C. ; Strachan, D.P.* ; Smith, N.L.* ; Folsom, A.R.*

Association of novel genetic Loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts.

Circ. Cardiovasc. Genet. 2, 125-133 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Background: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. Methods and Results: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P<5.0x10^-8). These included a single-nucleotide polymorphism located in the fibrinogen β chain (FGB) gene and 3 single-nucleotide polymorphisms representing newly identified loci. The high-signal single-nucleotide polymorphisms were rs1800789 in exon 7 of FGB (P=1.8x10^-30), rs2522056 downstream from the interferon regulatory factor 1 (IRF1) gene (P=1.3x10^-15), rs511154 within intron 1 of the propionyl coenzyme A carboxylase (PCCB) gene P=5.9x10^-10), and rs1539019 on the NLR family pyrin domain containing 3 isoforms (NLRP3) gene P=1.04x10^-8). Conclusions: Our findings highlight biological pathways that may be important in regulation of inflammation underlying cardiovascular disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords genome-wide association study;fibrinoge; genes; meta-analysis
ISSN (print) / ISBN 1942-325X
e-ISSN 1942-3268
Journal Circulation: Cardiovascular Genetics
Quellenangaben Volume: 2, Issue: 1, Pages: 125-133 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Hagerstown, Md
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)