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Impact of the lymphoma idiotype on in vivo tumor protection in a vaccination model based on targeting antigens to antigen-presenting cells.
Blood 99, 1327-1331 (2002)
Trioma cell vaccination is a potent new immunologic approach for the therapy of malignant B-cell lymphoma. It is based on targeting tumor antigens to internalizing receptors on antigen-presenting cells (APCs). Tumor cells are fused to an APC-specific hybridoma, where they are converted to trioma cells that include potentially all lymphoma-derived antigens and that express the APC-binding arm. In this study, the mechanisms of, trioma-mediated tumor immunity in immunocompetent mice were dissected, and it was shown in this model system that humoral anti-idiotypic immunity is indeed detectable after idiotype-specific immunization but that it does not reflect the degree of tumor protection obtained in vivo. Immunization against the idiotype alone was not sufficient for efficient tumor rejection in vivo. Targeting tumor antigens to APCs Is only successful in terms of inducing tumor protection when designed as a polyvalent vaccination protocol.
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9.273
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13
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
BLOOD DENDRITIC CELLS; EFFICIENT PRESENTATION; BISPECIFIC ANTIBODIES; B-CELLS; CD64; MOLECULES; CHAIN; MICE
Language
english
Publication Year
2002
HGF-reported in Year
2002
ISSN (print) / ISBN
0006-4971
e-ISSN
1528-0020
Journal
Blood
Quellenangaben
Volume: 99,
Pages: 1327-1331
Publisher
American Society of Hematology
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501700-006
Erfassungsdatum
2002-06-17