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de Hartog, J.J.* ; Hoek, G.* ; Peters, A. ; Timonen, K.L.* ; Ibald-Mulli, A. ; Brunekreef, B.* ; Heinrich, J. ; Tiittanen, P.* ; van Wijnen, J.H.* ; Kreyling, W.G. ; Kulmala, M.* ; Pekkanen, J.*

Effects of Fine and Ultrafine Particles on Cardiorespiratory Symptoms in Elderly Subjects with Coronary Heart Disease. The ULTRA Study.

Am. J. Epidemiol. 157, 613-623 (2003)

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The ULTRA Study, a study investigating the association between fine and ultrafine particulate air pollution and cardiorespiratory health, was conducted during the winter of 1998–1999 in Amsterdam, the Netherlands; Erfurt, Germany; and Helsinki, Finland. At each study center, a panel of elderly subjects with coronary heart disease recorded cardiac and respiratory symptoms in a diary. Exposure to ambient air pollution was characterized by measuring daily mass concentrations of particles smaller than 10 µm (PM₁₀) and 2.5 µm (PM_2.5), number concentrations of ultrafine particles (NC_0.01–0.1), and gases. Odds ratios for the relation of symptoms to air pollution, adjusted for time trend, respiratory infections, and meteorologic variables, were mostly homogeneous across the centers. No association was found between air pollution and chest pain. A 10-µg/m³ increase in PM_2.5 was positively associated with the incidence of shortness of breath (odds ratio (OR) = 1.12, 95% confidence interval (CI): 1.02, 1.24) and with avoidance of activities (OR = 1.09, 95% CI: 0.97, 1.22). NC_0.01–0.1 was only associated with the prevalence of avoidance of activities (OR = 1.10, 95% CI: 1.01, 1.19). In conclusion, PM_2.5 was associated with some cardiac symptoms in three panels of elderly subjects. PM_2.5was more strongly related to cardiorespiratory symptoms than ultrafine particles were.

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