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Thieme, S.F.* ; Möller, W. ; Becker, S.* ; Schuschnig, U.* ; Eickelberg, O. ; Helck, A.D.* ; Reiser, M.F.* ; Johnson, T.R.C.*

Ventilation imaging of the paranasal sinuses using xenon-enhanced dynamic single-energy CT and dual-energy CT: A feasibility study in a nasal cast.

Eur. Radiol. 22, 2110-2116 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
To show the feasibility of dual-energy CT (DECT) and dynamic CT for ventilation imaging of the paranasal sinuses in a nasal cast. In a first trial, xenon gas was administered to a nasal cast with a laminar flow of 7 L/min. Dynamic CT acquisitions of the nasal cavity and the sinuses were performed. This procedure was repeated with pulsating xenon flow. Local xenon concentrations in the different compartments of the model were determined on the basis of the enhancement levels. In a second trial, DECT measurements were performed both during laminar and pulsating xenon administration and the xenon concentrations were quantified directly. Neither with dynamic CT nor DECT could xenon-related enhancement be detected in the sinuses during laminar airflow. Using pulsating flow, dynamic imaging showed a xenon wash-in and wash-out in the sinuses that followed a mono-exponential function with time constants of a few seconds. Accordingly, DECT revealed xenon enhancement in the sinuses only after pulsating xenon administration. The feasibility of xenon-enhanced DECT for ventilation imaging was proven in a nasal cast. The superiority of pulsating gas flow for the administration of gas or aerosolised drugs to the paranasal sinuses was demonstrated. aEuro cent Ventilation of the paranasal sinuses is poorly understood. aEuro cent Dual-energy CT ventilation imaging has been explored using phantom simulation. aEuro cent Xenon can be seen in the paranasal sinuses using pulsating xenon flow. aEuro cent Dual-energy CT uses a lower radiation dose compared with dynamic ventilation CT.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Chronic Rhinosinusitis ; Crs ; Dual-energy Ct ; Ventilation Imaging ; Xenon; Pulsating Air-Flow; Computed-Tomography; Drug-Delivery
ISSN (print) / ISBN 0938-7994
e-ISSN 1432-1084
Journal European Radiology
Quellenangaben Volume: 22, Issue: 10, Pages: 2110-2116 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)
Institute of Lung Biology (LHI)