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Open Access Green as soon as Postprint is submitted to ZB.
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Autoimmunity 45, 568-573 (2012)
Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Apoptosis; chemotaxis; 'find-me' signal; lysophosphatidylcholine; ATP-binding cassette transporter; TANGIER-DISEASE; CELL-DEATH; ENGULFMENT; CLEARANCE; PHAGOCYTOSIS; MIGRATION; ELEGANS; ABC1; ACT
ISSN (print) / ISBN
0891-6934
e-ISSN
1607-842X
Journal
Autoimmunity
Quellenangaben
Volume: 45,
Issue: 8,
Pages: 568-573
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)
Institute of Experimental Genetics (IEG)