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Bradley, A.* ; Anastassiadis, K.* ; Ayadi, A.* ; Battey, J.F.* ; Bell, C.* ; Birling, M.-C.* ; Bottomley, J.* ; Brown, S.D.* ; Bürger, A. ; Bult, C.J.* ; Bushell, W.* ; Collins, F.S.* ; Desaintes, C.* ; Doe, B.* ; Economides, A.* ; Eppig, J.T.* ; Finnell, R.H.* ; Fletcher, C.* ; Fray, M.* ; Frendewey, D.* ; Friedel, R.H. ; Grosveld, F.G.* ; Hansen, J. ; Herault, Y.* ; Hicks, G.* ; Hörlein, A. ; Houghton, R.* ; Hrabě de Angelis, M. ; Huylebroeck, D.* ; Iyer, V.* ; de Jong, P.J.* ; Kadin, J.A.* ; Kaloff, C. ; Kennedy, K.* ; Koutsourakis, M.* ; Lloyd, K.C.K.* ; Marschall, S. ; Mason, J.* ; McKerlie, C.* ; McLeod, M.P.* ; von Melchner, H.* ; Moore, M.* ; Mujica, A.O.* ; Nagy, A.* ; Nefedov, M.* ; Nutter, L.M.* ; Pavlovic, G.* ; Peterson, J.L.* ; Pollock, J.* ; Ramirez-Solis, R.* ; Rancourt, D.E.* ; Raspa, M.* ; Remacle, J.E.* ; Ringwald, M.* ; Rosen, B.* ; Rosenthal, N.* ; Rossant, J.* ; Ruiz Noppinger, P.* ; Ryder, E.* ; Schick, J. ; Schnütgen, F.* ; Schofield, P.* ; Seisenberger, C. ; Selloum, M.* ; Simpson, E.M.* ; Skarnes, W.C.* ; Smedley, D.* ; Stanford, W.L.* ; Francis Stewart, A.* ; Stone, K.* ; Swan, K.* ; Tadepally, H.* ; Teboul, L.* ; Tocchini-Valentini, G.P.* ; Valenzuela, D.* ; West, A.P.* ; Yamamura, K.* ; Yoshinaga, Y.* ; Wurst, W.

The mammalian gene function resource: The International Knockout Mouse Consortium.

Mamm. Genome 23, 580-586 (2012)
Publ. Version/Full Text Volltext DOI PMC
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Open Access Green as soon as Postprint is submitted to ZB.
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
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Publication type Article: Journal article
Document type Scientific Article
Keywords EMBRYONIC STEM-CELLS; GENOME
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Journal Mammalian Genome
Quellenangaben Volume: 23, Issue: 9-10, Pages: 580-586 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30204 - Cell Programming and Repair
30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
G-500600-003
PubMed ID 22968824
DOI 10.1007/s00335-012-9422-2
WOS ID WOS:000309543200010
Scopus ID 84867332476
Erfassungsdatum 2012-10-23
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