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Bradley, A.* ; Anastassiadis, K.* ; Ayadi, A.* ; Battey, J.F.* ; Bell, C.* ; Birling, M.-C.* ; Bottomley, J.* ; Brown, S.D.* ; Bürger, A. ; Bult, C.J.* ; Bushell, W.* ; Collins, F.S.* ; Desaintes, C.* ; Doe, B.* ; Economides, A.* ; Eppig, J.T.* ; Finnell, R.H.* ; Fletcher, C.* ; Fray, M.* ; Frendewey, D.* ; Friedel, R.H. ; Grosveld, F.G.* ; Hansen, J. ; Herault, Y.* ; Hicks, G.* ; Hörlein, A. ; Houghton, R.* ; Hrabě de Angelis, M. ; Huylebroeck, D.* ; Iyer, V.* ; de Jong, P.J.* ; Kadin, J.A.* ; Kaloff, C. ; Kennedy, K.* ; Koutsourakis, M.* ; Lloyd, K.C.K.* ; Marschall, S. ; Mason, J.* ; McKerlie, C.* ; McLeod, M.P.* ; von Melchner, H.* ; Moore, M.* ; Mujica, A.O.* ; Nagy, A.* ; Nefedov, M.* ; Nutter, L.M.* ; Pavlovic, G.* ; Peterson, J.L.* ; Pollock, J.* ; Ramirez-Solis, R.* ; Rancourt, D.E.* ; Raspa, M.* ; Remacle, J.E.* ; Ringwald, M.* ; Rosen, B.* ; Rosenthal, N.* ; Rossant, J.* ; Ruiz Noppinger, P.* ; Ryder, E.* ; Schick, J. ; Schnütgen, F.* ; Schofield, P.* ; Seisenberger, C. ; Selloum, M.* ; Simpson, E.M.* ; Skarnes, W.C.* ; Smedley, D.* ; Stanford, W.L.* ; Francis Stewart, A.* ; Stone, K.* ; Swan, K.* ; Tadepally, H.* ; Teboul, L.* ; Tocchini-Valentini, G.P.* ; Valenzuela, D.* ; West, A.P.* ; Yamamura, K.* ; Yoshinaga, Y.* ; Wurst, W.

The mammalian gene function resource: The International Knockout Mouse Consortium.

Mamm. Genome 23, 580-586 (2012)
Publ. Version/Full Text Volltext DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords EMBRYONIC STEM-CELLS; GENOME
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Journal Mammalian Genome
Quellenangaben Volume: 23, Issue: 9-10, Pages: 580-586 Article Number: , Supplement: ,
Publisher Springer
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)