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Butterfield, L.H.* ; Disis, M.L.* ; Fox, BA.* ; Lee, PP.* ; Khleif, SN.* ; Thurin, M.* ; Trinchieri, G.* ; Wang, E.* ; Wigginton, J.* ; Chaussabel, D.* ; Coukos, G.* ; Dhodapkar, M.* ; Håkansson, L.* ; Janetzki, S.* ; Kleen, T.O.* ; Kirkwood, J.M.* ; Maccalli, C.* ; Maecker, H.* ; Maio, M.* ; Malyguine, A.* ; Masucci, G.* ; Palucka, A.K.* ; Potter, D.M.* ; Ribas, A.* ; Rivoltini, L.* ; Schendel, D.J.* ; Seliger, B.* ; Selvan, S.* ; Slingluff Jr., C.L.* ; Stroncek, D.F.* ; Streicher, H.* ; Wu, X.* ; Zeskind, B.* ; Zhao, Y.* ; Zocca, M.B.* ; Zwierzina, H.* ; Marincola, F.M.*

A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers".

J. Transl. Med. 6:81 (2008)
Publ. Version/Full Text Volltext DOI PMC
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The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the identification of relevant parameters to assist clinical and basic scientists who study the natural course of host/tumor interactions or their response to immune manipulation. The task force has two primary goals: 1) identify best practices of standardized and validated immune monitoring procedures and assays to promote inter-trial comparisons and 2) develop strategies for the identification of novel biomarkers that may enhance our understating of principles governing human cancer immune biology and, consequently, implement their clinical application. Two working groups were created that will report the developed best practices at an NCI/FDA/iSBTc sponsored workshop tied to the annual meeting of the iSBTc to be held in Washington DC in the Fall of 2009. This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document.
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Publication type Article: Journal article
Document type Editorial
Keywords CYTOKINE FLOW-CYTOMETRY; EXPRESSION ANALYSIS; CANCER; CELLS; INTERLEUKIN-2; TETRAMER; ELISPOT; CRYOPRESERVATION; MELANOMA; THERAPY
Language english
Publication Year 2008
HGF-reported in Year 0
ISSN (print) / ISBN 1479-5876
e-ISSN 1479-5876
Journal Journal of Translational Medicine
Quellenangaben Volume: 6, Issue: , Pages: , Article Number: 81 Supplement: ,
Publisher BioMed Central
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
CCG Immune Monitoring (Platform) (IMI-KIM)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s) G-501700-005
G-501700-001
G-501700-002
G-520400-001
PubMed ID 19105846
DOI 10.1186/1479-5876-6-81
WOS ID 000263537200001
Erfassungsdatum 2008-12-31
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