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Raue, A.* ; Kreutz, C.* ; Theis, F.J. ; Timmer, J.

Joining forces of Bayesian and frequentist methodology: A study for inference in the presence of non-identiability.

Philos. Trans. R. Soc. A - Math. Phys. Eng. Sci. 371:20110544 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Increasingly complex applications involve large datasets in combination with nonlinear and high dimensional mathematical models. In this context, statistical inference is a challenging issue that calls for pragmatic approaches that take advantage of both Bayesian and frequentist methods. The elegance of Bayesian methodology is founded in the propagation of information content provided by experimental data and prior assumptions to the posterior probability distribution of model predictions. However, for complex applications experimental data and prior assumptions potentially constrain the posterior probability distribution insuciently. In these situations Bayesian Markov chain Monte Carlo sampling can be infeasible. From a frequentist point of view insucient experimental data and prior assumptions can be interpreted as non-identi ability. The pro le likelihood approach o ers to detect and to resolve non-identi ability by experimental design iteratively. Therefore, it allows one to better constrain the posterior probability distribution until Markov chain Monte Carlo sampling can be used securely. Using an application from cell biology we compare both methods and show that a successive application of both methods facilitates a realistic assessment of uncertainty in model predictions.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords identi ability, pro le likelihood, Bayesian Markov chain Monte Carlo sampling, posterior propriety, propagation of uncertainty, prediction uncertainty; Profile Likelihood ; Improper Priors ; Models ; Range
ISSN (print) / ISBN 1364-503X
e-ISSN 1471-2962
Journal Philosophical Transactions of the Royal Society of London, Series A
Quellenangaben Volume: 371, Issue: 1984, Pages: , Article Number: 20110544 Supplement: ,
Publisher Royal Society of London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)