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Genetic variation in metabolic phenotypes: Study designs and applications.
Nat. Rev. Genet. 13, 759-769 (2012)
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Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences on metabolic phenotypes is key to a systems-wide understanding of their interactions with environmental and lifestyle factors in their aetiology, and we can now explore the genetics of large panels of metabolic traits by coupling genome-wide association studies and metabolomics. These genome-wide association studies are beginning to unravel the genetic contribution to human metabolic individuality and to demonstrate its relevance for biomedical and pharmaceutical research. Adopting the most appropriate study designs and analytical tools is paramount to further refining the genotype-phenotype map and eventually identifying the part played by genetic influences on metabolic phenotypes. We discuss such design considerations and applications in this Review.
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Times Cited
Times Cited
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38.075
3.565
116
135
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Publication type
Article: Journal article
Document type
Review
Keywords
GENOME-WIDE ASSOCIATION; HDL-CHOLESTEROL CONCENTRATIONS; CHRONIC KIDNEY-DISEASE; COMMON VARIANTS; SUSCEPTIBILITY LOCI; BILIRUBIN LEVELS; ACID INTAKE; METAANALYSIS; INDIVIDUALITY; INTERACTS
Language
english
Publication Year
2012
HGF-reported in Year
2012
ISSN (print) / ISBN
1471-0056
e-ISSN
1471-0064
Journal
Nature Reviews - Genetics
Quellenangaben
Volume: 13,
Issue: 11,
Pages: 759-769
Publisher
Nature Publishing Group
Reviewing status
Peer reviewed
Institute(s)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Genetic Epidemiology (IGE)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s)
30505 - New Technologies for Biomedical Discoveries
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Enabling and Novel Technologies
Genetics and Epidemiology
Genetics and Epidemiology
PSP Element(s)
G-503700-001
G-504100-001
G-504100-001
PubMed ID
23032255
DOI
10.1038/nrg3314
WOS ID
WOS:000310218200006
Scopus ID
84867744660
Erfassungsdatum
2012-10-31