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Fuchs, H. ; Gailus-Durner, V. ; Neschen, S. ; Adler, T. ; Afonso, L.C. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Bohla, A. ; Calzada-Wack, J. ; Cohrs, C.M. ; Dewert, A. ; Fridrich, B. ; Garrett, L. ; Glasl, L. ; Götz, A. ; Hans, W. ; Hölter, S.M. ; Horsch, M. ; Hurt, A. ; Janas, E. ; Janik, D. ; Kahle-Stephan, M.* ; Kistler, M.* ; Klein-Rodewald, T. ; Lengger, C.* ; Ludwig, T.* ; Maier, H.* ; Marschall, S. ; Micklich, K. ; Möller, G. ; Naton, B. ; Prehn, C. ; Puk, O. ; Rácz, I.* ; Räß, M. ; Rathkolb, B. ; Rozman, J. ; Scheerer, M. ; Schiller, E. ; Schrewe, A. ; Steinkamp, R. ; Stoeger, C. ; Sun, M. ; Szymczak, W. ; Treise, I. ; Vargas Panesso, I.L. ; Vernaleken, A. ; Willershäuser, M. ; Zimprich, A. ; Zeh, R.M. ; Adamski, J. ; Beckers, J. ; Bekeredjian, R.* ; Busch, D.H.* ; Eickelberg, O. ; Favor, J. ; Graw, J. ; Höfler, H. ; Hoeschen, C. ; Katus, H.A.* ; Klingenspor, M.* ; Klopstock, T.* ; Neff, F. ; Ollert, M.* ; Schulz, H. ; Stöger, T. ; Wolf, E.* ; Wurst, W. ; Yildirim, A.Ö. ; Zimmer, A.* ; Hrabě de Angelis, M.

Innovations in phenotyping of mouse models in the German Mouse Clinic.

Mamm. Genome 23, 611-622 (2012)
Publ. Version/Full Text Volltext DOI PMC
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Open Access Green as soon as Postprint is submitted to ZB.
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("top-down projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).
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2.887
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37
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Publication type Article: Journal article
Document type Scientific Article
Keywords METASTASIS SUPPRESSOR-1; PARKINSONS-DISEASE; LANGUAGE DISORDER; TUMOR-SUPPRESSOR; DWARF MICE; GENE; SPEECH; MTSS1; UROMODULIN; CARCINOMA
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Journal Mammalian Genome
Quellenangaben Volume: 23, Issue: 9-10, Pages: 611-622 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Lung Health and Immunity (LHI)
Institute of Human Genetics (IHG)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Research Unit Medical Radiation Physics and Diagnostics (AMSD)
Institute for Allergy Research (IAF)
Institute of Epidemiology (EPI)
POF-Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
80000 - German Center for Lung Research
30503 - Chronic Diseases of the Lung and Allergies
90000 - German Center for Diabetes Research
Research field(s) Genetics and Epidemiology
Lung Research
Enabling and Novel Technologies
Radiation Sciences
Allergy
PSP Element(s) G-500600-003
G-500600-001
G-505600-001
G-500600-004
G-505000-001
G-500700-002
G-500500-002
G-500300-001
G-503600-001
G-500500-001
G-501800-541
G-504000-002
G-503900-003
G-505000-007
G-501600-001
G-501900-062
G-503600-002
G-500600-002
PubMed ID 22926221
DOI 10.1007/s00335-012-9415-1
WOS ID WOS:000309543200013
Scopus ID 84867329301
Erfassungsdatum 2012-10-31
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