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Zeltser, L.M.* ; Seeley, R.J.* ; Tschöp, M.H.

Synaptic plasticity in neuronal circuits regulating energy balance.

Nat. Neurosci. 15, 1336-1342 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Maintaining energy balance is of paramount importance for metabolic health and survival. It is achieved through the coordinated regulation of neuronal circuits that control a wide range of physiological processes affecting energy intake and expenditure, such as feeding, metabolic rate, locomotor activity, arousal, growth and reproduction. Neuronal populations distributed throughout the CNS but highly enriched in the mediobasal hypothalamus, sense hormonal, nutrient and neuronal signals of systemic energy status and relay this information to secondary neurons that integrate the information and regulate distinct physiological parameters in a manner that promotes energy homeostasis. To achieve this, it is critical that neuronal circuits provide information about short-term changes in nutrient availability in the larger context of long-term energy status. For example, the same signals lead to different cellular and physiological responses if delivered under fasted versus fed conditions. Thus, there is a clear need to have mechanisms that rapidly and reversibly adjust responsiveness of hypothalamic circuits to acute changes in nutrient availability.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords HYPOTHALAMIC ARCUATE NUCLEUS; AGOUTI-RELATED PROTEIN; VENTRAL TEGMENTAL AREA; DIET-INDUCED OBESITY; PROOPIOMELANOCORTIN NEURONS; FEEDING CIRCUITS; NEUROPEPTIDE-Y; POMC NEURONS; INPUT ORGANIZATION; NPY/AGRP NEURONS
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Journal Nature Neuroscience
Quellenangaben Volume: 15, Issue: 10, Pages: 1336-1342 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)