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Open Access Green as soon as Postprint is submitted to ZB.
Molecular live cell bioimaging in stem cell research.
Ann. NY Acad. Sci. 1266, 18-27 (2012)
Functional heterogeneity within stem and progenitor cells has been shown to influence cell fate decisions. Similarly, intracellular signaling activated by external stimuli is highly heterogeneous and its spatiotemporal activity is linked to future cell behavior. To quantify these heterogeneous states and link them to future cell fates, it is important to observe cell populations continuously with single cell resolution. Live cell imaging in combination with fluorescent biosensors for signaling activity serves as a powerful tool to study cellular and molecular heterogeneity and the long-term biological effects of signaling. Here, we describe these methodologies, their advantages over classical approaches, and we illustrate how they could be applied to improve our understanding of the importance of heterogeneous cellular and molecular responses to external signaling cues.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
3.155
1.083
8
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
biosensors; cytokines; M-CSF; signaling; lineage choice; stem cell; imaging; time lapse; Protein-Kinase-C; Stimulating Factor-I; Hematopoietic Progenitor Cells; Infrared Fluorescent Proteins; Receptor Tyrosine Kinase; M-Csf Receptor; Self-Renewal; Lineage Commitment; Living Cells; Scaffolding Protein
Language
english
Publication Year
2012
HGF-reported in Year
2012
ISSN (print) / ISBN
0077-8923
e-ISSN
1749-6632
Quellenangaben
Volume: 1266,
Issue: 1,
Pages: 18-27
Publisher
New York Academy of Sciences
Reviewing status
Peer reviewed
Institute(s)
Research Unit Stem Cell Dynamics (SCD)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-501200-001
PubMed ID
22901252
WOS ID
WOS:000312595400004
Scopus ID
84865352787
Erfassungsdatum
2012-11-08