PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Imamura, M.* ; Maeda, S.* ; Yamauchi, T.* ; Hara, K.* ; Yasuda, K.* ; Morizono, T.* ; Takahashi, A.* ; Horikoshi, M.* ; Nishimura, M.* ; Fujita, H.* ; Tsunoda, T.* ; Kubo, M.* ; Watada, H.* ; Maegawa, H.* ; Okada-Iwabu, M.* ; Iwabu, M.* ; Shojima, N.* ; Ohshige, T.* ; Omori, S.* ; Iwata, M.* ; Hirose, H.* ; Kaku, K.* ; Ito, C.* ; Tanaka, Y.* ; Tobe, K.* ; Kashiwagi, A.* ; Kawamori, R.* ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T.) ; Kasuga, M.* ; Kamatani, N.*

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.

Hum. Mol. Genet. 21, 3042-3049 (2012)
Publ. Version/Full Text Volltext DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
To identify a novel susceptibility locus for type 2 diabetes, we performed an imputation-based, genome-wide association study (GWAS) in a Japanese population using newly obtained imputed-genotype data for 2 229 890 single-nucleotide polymorphisms (SNPs) estimated from previously reported, directly genotyped GWAS data in the same samples (stage 1: 4470 type 2 diabetes versus 3071 controls). We directly genotyped 43 new SNPs with P-values of <10(-4) in a part of stage-1 samples (2692 type 2 diabetes versus 3071 controls), and the associations of validated SNPs were evaluated in another 11 139 Japanese individuals (stage 2: 7605 type 2 diabetes versus 3534 controls). Combined meta-analysis using directly genotyped data for stages 1 and 2 revealed that rs515071 in ANK1 and rs7656416 near MGC21675 were associated with type 2 diabetes in the Japanese population at the genome-wide significant level (P < 5 × 10(-8)). The association of rs515071 was also observed in European GWAS data (combined P for all populations = 6.14 × 10(-10)). Rs7656416 was in linkage disequilibrium to rs6815464, which had recently been identified as a top signal in a meta-analysis of East Asian GWAS for type 2 diabetes (r(2) = 0.76 in stage 2). The association of rs7656416 with type 2 diabetes disappeared after conditioning on rs6815464. These results indicate that the ANK1 locus is a new, common susceptibility locus for type 2 diabetes across different ethnic groups. The signal of association was weaker in the directly genotyped data, so the improvement in signal indicates the importance of imputation in this particular case.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.636
1.710
74
78
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords GENOME-WIDE ASSOCIATION; LARGE-SCALE ASSOCIATION; INTRAMUSCULAR FAT; RISK LOCI; GENE; REPLICATION; VARIANTS; ANKYRIN-1; PATHWAYS; PROMOTER
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Journal Human Molecular Genetics
Quellenangaben Volume: 21, Issue: 13, Pages: 3042-3049 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504200-002
G-504100-001
G-503900-001
G-503900-002
PubMed ID 22456796
DOI 10.1093/hmg/dds113
WOS ID WOS:000305457700017
Erfassungsdatum 2012-11-08
[➜Report correction]