OpenSSL SSL_connect: Connection reset by peer in connection to v2.sherpa.ac.uk:443 PuSH - Publication Server of Helmholtz Zentrum München: Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

PuSH - Publication Server of Helmholtz Zentrum München

Little, M.P.* ; Azizova, T.V.* ; Bazyka, D.* ; Bouffler, S.D.* ; Cardis, E.* ; Chekin, S.* ; Chumak, V.V.* ; Cucinotta, F.A.* ; de Vathaire, F.* ; Hall, P.* ; Harrison, J.D.* ; Hildebrandt, G.* ; Ivanov, V.* ; Kashcheev, V.V.* ; Klymenko, S.V.* ; Kreuzer, M.* ; Laurent, O.* ; Ozasa, K.* ; Schneider, T.* ; Tapio, S. ; Taylor, A.M.* ; Tzoulaki, I.* ; Vandoolaeghe, W.L.* ; Wakeford, R.* ; Zablotska, L.B.* ; Zhang, W.* ; Lipshultz, S.E.*

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

Environ. Health Perspect. 120, 1503-1511 (2012)
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Background: Although high doses of ionizing radiation have long been linked to circulatory disease, evidence for an association at lower exposures remains controversial. However, recent analyses suggest excess relative risks at occupational exposure levels.Objectives: We performed a systematic review and meta-analysis to summarize information on circulatory disease risks associated with moderate- and low-level whole-body ionizing radiation exposures.Methods: We conducted PubMed/ISI Thomson searches of peer-reviewed papers published since 1990 using the terms "radiation" AND "heart" AND "disease," OR "radiation" AND "stroke," OR "radiation" AND "circulatory" AND "disease." Radiation exposures had to be whole-body, with a cumulative mean dose of < 0.5 Sv, or at a low dose rate (< 10 mSv/day). We estimated population risks of circulatory disease from low-level radiation exposure using excess relative risk estimates from this meta-analysis and current mortality rates for nine major developed countries.Results: Estimated excess population risks for all circulatory diseases combined ranged from 2.5%/Sv [95% confidence interval (CI): 0.8, 4.2] for France to 8.5%/Sv (95% CI: 4.0, 13.0) for Russia.Conclusions: Our review supports an association between circulatory disease mortality and low and moderate doses of ionizing radiation. Our analysis was limited by heterogeneity among studies (particularly for noncardiac end points), the possibility of uncontrolled confounding in some occupational groups by lifestyle factors, and higher dose groups (> 0.5 Sv) generally driving the observed trends. If confirmed, our findings suggest that overall radiation-related mortality is about twice that currently estimated based on estimates for cancer end points alone (which range from 4.2% to 5.6%/Sv for these populations).
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords cancer; circulatory disease; heart disease; radiation; stroke; ATOMIC-BOMB SURVIVORS; CORONARY-HEART-DISEASE; POWER INDUSTRY WORKERS; NUCLEAR-FUELS PLC; LOW-DOSE EXPOSURE; CARDIOVASCULAR-DISEASE; EPIDEMIOLOGIC EVIDENCE; MAYAK PA; CANCER; COHORT
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Journal Environmental Health Perspectives
Quellenangaben Volume: 120, Issue: 11, Pages: 1503-1511 Article Number: , Supplement: ,
Publisher Research Triangle Park
Publishing Place NC [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)