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Fischer, A.* ; Grallert, H. ; Böhme, M.* ; Gieger, C. ; Boomgaarden, I.* ; Heid, I.M. ; Wichmann, H.-E. ; Döring, F.* ; Illig, T.

Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.

Genet. Test. Mol. Biomark. 13, 223-226 (2009)

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Context: The H-allele of the R298H polymorphism in the prostaglandin E synthase 2 (PTGES2) gene was associated with lower risk of diabetes type 2. Aim: To explore the association between the PTGES2 R298H SNP and body mass index (BMI). Methods: We analyzed the R298H SNP (rs13283456) and three haplotype single-nucleotide polymorphisms (rs884115, rs10987883, and rs4837240) covering a 20 kb gene region in population-based surveys of the Kooperative Gesundheitsforschung in der Region Augsburg study cohort with 8079 participants. Results: A statistically significant difference in BMI between the heterozygous PTGES2 R298H genotype and the homozygous R/R genotype was found in males but not in females. Males with the R/H genotype showed a decrease in BMI of-0.30 BMI units (95% CI:-0.55,-0.04, p = 0.02) in comparison to R/R males. A haplotype comprising the minor allele of PTGES2 R298H showed a significant decrease of-0.23 BMI units in males (-0.45,-0.02; p = 0.04) but not in females. Other haplotypes and haplotype single-nucleotide polymorphisms were not significantly associated with BMI. Conclusion: We found a marginal but significant influence of the PTGES2 298H SNP on BMI in a large population-based study.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords ptges2 arg298his polymorphism; adipose-tissue; leptin release; obesity; gene; rat; childhood; variant; pge(2); adult

ISSN (print) / ISBN 1090-6576

e-ISSN 1557-7473

Journal Genetic Testing and Molecular Biomarkers

Quellenangaben Volume: 13, Issue: 2, Pages: 223-226

Publisher Mary Ann Liebert

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)