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Kullmann, S. ; Pape, A.-A.* ; Heni, M.* ; Ketterer, C.* ; Schick, F.* ; Häring, H.-U. ; Fritsche, A. ; Preissl, H. ; Veit, R.*

Functional network connectivity underlying food processing: Disturbed salience and visual processing in overweight and obese adults.

Cereb. Cortex 23, 1247-1256 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In order to adequately explore the neurobiological basis of eating behavior of humans and their changes with body weight, interactions between brain areas or networks need to be investigated. In the current functional magnetic resonance imaging study, we examined the modulating effects of stimulus category (food vs. nonfood), caloric content of food, and body weight on the time course and functional connectivity of 5 brain networks by means of independent component analysis in healthy lean and overweight/obese adults. These functional networks included motor sensory, default-mode, extrastriate visual, temporal visual association, and salience networks. We found an extensive modulation elicited by food stimuli in the 2 visual and salience networks, with a dissociable pattern in the time course and functional connectivity between lean and overweight/obese subjects. Specifically, only in lean subjects, the temporal visual association network was modulated by the stimulus category and the salience network by caloric content, whereas overweight and obese subjects showed a generalized augmented response in the salience network. Furthermore, overweight/obese subjects showed changes in functional connectivity in networks important for object recognition, motivational salience, and executive control. These alterations could potentially lead to top-down deficiencies driving the overconsumption of food in the obese population.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords fMRI; food; functional connectivity; ICA; obesity; Independent Component Analysis ; High-calorie Foods ; Default-mode ; Working-memory ; Cingulate Cortex ; Brain Activity ; Activation ; Schizophrenia ; Pictures ; Reward
ISSN (print) / ISBN 1047-3211
e-ISSN 1460-2199
Journal Cerebral Cortex
Quellenangaben Volume: 23, Issue: 5, Pages: 1247-1256 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)