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Wilde, S. ; Schendel, D.J.

High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them.

OncoImmunology 1, 1643-1644 (2012)

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Open Access Green as soon as Postprint is submitted to ZB.

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The adoptive transfer of lymphocytes expressing high-avidity T-cell receptors with antitumor specificity provides a promising therapy for cancer patients. Recently, we compared 12 HLA-A2-restricted, tyrosinase peptide-specific CD8⁺ cytotoxic T-lymphocyte (CTL) clones and demonstrated that polyfunctional type 1 helper (Th1)-cytokine secretion serves to rapidly select high-quality, high-avidity CTLs.

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Publication type Article: Journal article

Document type Other: Opinion

Corresponding Author

Keywords Adoptive T Cell Therapy ; Human Cytotoxic Cd8(+) T Lymphocytes ; Melanoma ; T-cell Receptor ; Tcr Gene Therapy ; Th1/th2 Polycytokines; Receptor Gene-therapy ; Cancer ; Sensitivity ; Recognition ; Tcr

ISSN (print) / ISBN 2162-4011

e-ISSN 2162-402X

Journal OncoImmunology

Quellenangaben Volume: 1, Issue: 9, Pages: 1643-1644

Publisher Taylor & Francis

Publishing Place Philadelphia

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)