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Open Access Green as soon as Postprint is submitted to ZB.
The role of ghrelin in the control of energy balance.
In: Appetite Control. Berlin ; Heidelberg: Springer, 2012. 161-184 (Handb. Exp. Pharmacol. ; 209)
Ghrelin is the only potent orexigenic peptide in circulation. It stimulates food intake and leads to positive energy balance, adipogenesis, and body weight gain. However, the physiological significance of ghrelin in the regulation of energy homeostasis is controversial, since loss of ghrelin function in rodents does not necessarily lead to anorexia and weight loss. In this chapter, we discuss the metabolic function of ghrelin and are highlighting recent findings including the discovery and function of ghrelin-acylating enzyme ghrelin O-acyltransferase (GOAT). Based on available published data, we conclude that ghrelin is a principally important endogenous regulator of energy balance, which however may affect both food intake and systemic metabolism via independent mechanisms. Importantly, ghrelin, when acylated by GOAT, might represent a key molecular link between the sensing of consumed calories and the neuroendocrine control of energy homeostasis. Thus, agents antagonizing the action of ghrelin may have therapeutic potential in the therapy of obesity.
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Publication type
Article: Edited volume or book chapter
Editors
Joost, H.-G.*
Keywords
Ghrelin; Ghrelin-O-acyltransferase; Ghrelin activation; Stimulation of food intake
ISSN (print) / ISBN
0171-2004
ISBN
978-3-642-24715-6
Book Volume Title
Appetite Control
Quellenangaben
Volume: 209,
Pages: 161-184
Publisher
Springer
Publishing Place
Berlin ; Heidelberg
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)