PuSH - Publication Server of Helmholtz Zentrum München: Fraction of unsaturated fatty acids in Visceral Adipose Tissue (VAT) is lower in subjects with high total VAT volume - a combined <sup>1</sup>H MRS and volumetric MRI study in male subjects.

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Machann, J. ; Stefan, N. ; Schabel, C.* ; Schleicher, E.D. ; Fritsche, A. ; Würslin, C.* ; Häring, H.-U. ; Claussen, C.D.* ; Schick, F.*

Fraction of unsaturated fatty acids in Visceral Adipose Tissue (VAT) is lower in subjects with high total VAT volume - a combined ¹H MRS and volumetric MRI study in male subjects.

NMR Biomed. 26, 232-236 (2013)

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Visceral adipose tissue (VAT) is thought to play an important role in the pathogenesis of obesity and insulin resistance. However, little is known about the composition of VAT with regard to the amount of mono- (MUFAs) and polyunsaturated fatty acids (PUFAs) in triglycerides. Volume-selective MRS was performed in addition to MRI for the quantification of VAT. Analysis comprised proton signals from the vinyl-H group (H-C = C-H), including protons from MUFA + PUFA, and diallylic-H, i.e. methylene-interrupted PUFAs. The methyl (-CH(3) ) resonance, which is the only peak with a defined number of protons/triglyceride (n = 9), served as reference. Twenty male subjects participated in this prospective study and underwent MRS of VAT on a 3-T whole-body unit. Spectra were recorded by a single-voxel stimulated echo acquisition mode (STEAM) technique (TE/TM/TR = 20/10/4000 ms; volume of interest between 20 × 25 × 20 and 30 × 30 × 20 mm³; 48-80 acquisitions depending on the size of the volume of interest; bandwidth, 1200 Hz). Post-processing was performed by a Java-based magnetic resonance user interface (jMRUI; AMARES). The volume of VAT was quantified in a separate session on a 1.5-T imager a few days prior to the MRS session by T(1) -weighted imaging. The relative amount of VAT was calculated as a percentage of body weight (%VAT). Ratios of vinyl-H to -CH(3) and diallylic-H to -CH(3) were calculated. All spectra recorded from VAT were of high quality, enabling reliable quantification of the mentioned resonances. %VAT and vinyl-H/CH(3) varied over a broad range (2.8-8.3% and 0.45-0.64, respectively). A strong negative correlation between %VAT and vinyl-H/CH(3) was found (r = -0.92), whereas diallylic-H/CH(3) alone was clearly less well correlated with %VAT (r = -0.21). The composition of VAT shows strong interindividual variations. The greater the total amount of VAT, the less unsaturated the fatty acids. This is a preliminary result in mainly obese male subjects, and it remains to be determined whether this correlation holds for other cohorts of different age, gender and body mass index. Furthermore, changes in VAT composition during weight loss or different forms of diet have yet to be examined.

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PuSH - Publication Server of Helmholtz Zentrum München

Fraction of unsaturated fatty acids in Visceral Adipose Tissue (VAT) is lower in subjects with high total VAT volume - a combined 1H MRS and volumetric MRI study in male subjects.

Fraction of unsaturated fatty acids in Visceral Adipose Tissue (VAT) is lower in subjects with high total VAT volume - a combined ¹H MRS and volumetric MRI study in male subjects.