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Gündisch, S. ; Boeckeler, E. ; Behrends, U. ; Amtmann, E.* ; Ehrhardt, H. ; Jeremias, I.

Glucocorticoids augment survival and proliferation of tumor cells.

Anticancer Res. 32, 4251-4261 (2012)
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BACKGROUND: Glucocorticoids are widely used for cancer patients, although they can reduce the efficacy of anticancer treatment. MATERIALS AND METHODS: We characterized non-apoptotic actions of glucocorticoids on tumor cell lines, primary tumor cells and an in vivo model, together with molecular signaling studies. RESULTS: Glucocorticoids enhanced cell proliferation in 9/17 cell lines and significantly promoted tumor cell proliferation in a pre-clinical mouse model of lung carcinoma. 65/139 primary acute childhood leukemia samples were glucocorticoid-resistant. Both dexamethasone and prednisolone increased in vitro survival in 21/65 samples from glucocorticoid-resistant primary leukemias, revealing a completely new action of glucocorticoids. Dexamethasone-induced proliferation was mediated by glucocorticoid receptor and activated the proliferation signaling pathways of protein kinase B/AKT and p38 mitogen-activated protein kinase. CONCLUSION: Our data suggest that restriction of the use of glucocorticoids during anticancer treatment might improve the outcome of patients with solid tumors.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Tumor cell proliferation; glucocorticoids; glucocorticoid receptor; p38MAPK; AKT; ACUTE LYMPHOBLASTIC-LEUKEMIA; INDUCED APOPTOSIS; BRAIN METASTASES; LUNG-CANCER; DEXAMETHASONE; RECEPTOR; PHARMACOKINETICS; PREDNISOLONE; STIMULATION; PACLITAXEL
ISSN (print) / ISBN 0250-7005
e-ISSN 1791-7530
Journal Anticancer Research
Quellenangaben Volume: 32, Issue: 10, Pages: 4251-4261 Article Number: , Supplement: ,
Publisher International Institute of Anticancer Research
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)