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Lu, X.* ; Wang, L.* ; Chen, S.* ; He, L.* ; Yang, X.* ; Shi, Y.* ; Cheng, J.* ; Zhang, L.* ; Gu, C.C.* ; Huang, J.* ; Wu, T.* ; Ma, Y.* ; Li, J.* ; Cao, J.* ; Chen, J.* ; Ge, D.* ; Fan, Z.* ; Li, Y.* ; Zhao, L.* ; Li, H.* ; Zhou, X.* ; Chen, L.* ; Liu, D.* ; Duan, X.* ; Hao, Y.* ; Lu, F.* ; Liu, Z.* ; Yao, C.* ; Shen, C.* ; Pu, X.* ; Yu, L.* ; Fang, X.* ; Xu, L.* ; Mu, J.* ; Wu, X.* ; Zheng, R.* ; Wu, N.* ; Zhao, Q.* ; Liu, X.* ; Wang, M.* ; Yu, D.* ; Hu, D.* ; Ji, X.* ; Guo, D.* ; Sun, D.* ; Wang, Q.* ; Yang, Y.* ; Liu, F.* ; Mao, Q.* ; Liang, X.* ; Ji, J.* ; Chen, P.* ; Mo, X.* ; Li, D.* ; Chai, G.* ; Tang, Y.* ; Li, X.* ; Du, Z.* ; Dou, C.* ; Yang, Z.* ; Meng, Q.* ; Wang, D.* ; Wang, R.* ; Yang, J.* ; Schunkert, H.* ; Samani, N.J.* ; Kathiresan, S.* ; Reilly, M.P.* ; Erdmann, J.* ; Peng, X.* ; Chen, R.* ; Qiang, B.* ; Gu, D.* ; CARDIoGRAM Consortium (Wichmann, H.-E. ; Döring, A. ; Illig, T. ; Klopp, N. ; Meisinger, C. ; Peters, A. ; Meitinger, T.)

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Nat. Genet. 44, 890-894 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; COMMON VARIANTS; EAST ASIANS; METAANALYSIS; POPULATION; SEQUENCE; ONSET
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 44, Issue: 8, Pages: 890-894 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)