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Mellett, M.* ; Atzei, P.* ; Horgan, A.* ; Hams, E.* ; Floß, T. ; Wurst, W. ; Fallon, P.G.* ; Moynagh, P.N.*

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.

Nat. Commun. 3:1119 (2012)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Interleukin-17A, the prototypical member of the interleukin-17 cytokine family, coordinates local tissue inflammation by recruiting neutrophils to sites of infection. Dysregulation of interleukin-17 signalling has been linked to the pathogenesis of inflammatory diseases and autoimmunity. The interleukin-17 receptor family members (A-E) have a broad range of functional effects in immune signalling yet no known role has been described for the remaining orphan receptor, interleukin-17 receptor D, in regulating interleukin-17A-induced signalling pathways. Here we demonstrate that interleukin-17 receptor D can differentially regulate the various pathways employed by interleukin-17A. Neutrophil recruitment, in response to in vivo administration of interleukin-17A, is abolished in interleukin-17 receptor D-deficient mice, correlating with reduced interleukin-17A-induced activation of p38 mitogen-activated protein kinase and expression of the neutrophil chemokine MIP-2. In contrast, interleukin-17 receptor D deficiency results in enhanced interleukin-17A-induced activation of nuclear factor-kappa B and interleukin-6 and keratinocyte chemoattractant expression. Interleukin-17 receptor D disrupts the interaction of Act1 and TRAF6 causing differential regulation of nuclear factor-kappa B and p38 mitogen-activated protein kinase signalling pathways.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Pulmonary Inflammation ; Tnf-alpha ; Cells ; Interleukin-17 ; Expression ; Disease ; Autoimmune ; Chemokine ; Responses ; Sef
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 3, Issue: , Pages: , Article Number: 1119 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)