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Open Access Green as soon as Postprint is submitted to ZB.
Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
OncoImmunology 1, 129-140 (2012)
Designer T cells expressing transgenic T cell receptors (TCR) with anti-tumor specificity offer new treatment options for cancer patients. We developed a three phase procedure to identify T cells of high avidity based on the fact that T cells recognizing peptides presented by allogeneic MHC efficiently kill tumor cells. Autologous dendritic cells (DC) are co-transfected with ivt-RNA encoding an allogeneic MHC molecule and a selected antigen to allow them to express allogeneic MHC-peptide complexes that activate allo-restricted peptide-specific T cells. This approach provides great flexibility for obtaining high-avidity T cells as potential sources of TCR for adoptive T cell therapy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
human cytotoxic T lymphocytes; dendritic cells; adoptive T cell therapy; T cell receptor (TCR); TCR gene therapy
ISSN (print) / ISBN
2162-4011
e-ISSN
2162-402X
Journal
OncoImmunology
Quellenangaben
Volume: 1,
Issue: 2,
Pages: 129-140
Publisher
Taylor & Francis
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)