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Gastric inhibitory polypeptide receptor: Association analyses for obesity of several polymorphisms in large study groups.
BMC Med. Genet. 10:19 (2009)
Background: Gastric inhibitory polypeptide ( GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR. We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies. Methods: Genotyping was performed by MALDI-TOF, ARMS-PCR and RFLP. The family-study: 761 German families with at least one extremely obese child or adolescent (n = 1,041) and both parents ( n = 1,522). Case-control study: ( a) German obese children ( n = 333) and (b) obese adults ( n = 987) in comparison to 588 adult lean controls. The two cross-sectional population-based studies: KORA ( n = 8,269) and SHIP ( n = 4,310). Results: We detected over-transmission of the A-allele of rs2302382 in the German families (pTDT-Test = 0.0089). In the combined case-control sample, we estimated an odd ratio of 1.54 (95% CI 1.09; 2.19, pCA-Test = 0.014) for homozygotes of the rs2302382 A-allele compared to individuals with no A-allele. A similar trend was found in KORA where the rs2302382 A-allele led to an increase of 0.12 BMI units (p = 0.136). In SHIP, however, the A-allele of rs2302382 was estimated to contribute an average decrease of 0.27 BMI units (p-value = 0.031). Conclusion: Our data suggest a potential relevance of GIPR variants for obesity. However, additional studies are warranted in light of the conflicting results obtained in one of the two population-based studies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
GENOME-WIDE ASSOCIATION; GIP RECEPTOR; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; CUSHINGS-SYNDROME; KNOCKOUT MICE; BODY-WEIGHT; FTO GENE; VARIANTS; POPULATION
e-ISSN
1471-2350
Journal
BMC Medical Genetics
Quellenangaben
Volume: 10,
Article Number: 19
Publisher
BioMed Central
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)