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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source.
Proc. Natl. Acad. Sci. U.S.A. 109, 17880-17885 (2012)
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Grating Interferometer ; Pulmonary Emphysema ; X-ray Imaging; Phase-contrast Images ; Grating Interferometer ; Talbot Interferometry ; Computed-tomography ; Lung-tissue ; Copd ; Radiography ; Visualization ; Speckle ; Origin
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Volume: 109,
Issue: 44,
Pages: 17880-17885
Publisher
National Academy of Sciences
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)