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Schleede, S.* ; Meinel, F.G.* ; Bech, M.* ; Herzen, J.* ; Achterhold, K.* ; Potdevin, G.* ; Malecki, A.* ; Adam-Neumair, S.* ; Thieme, S.F.* ; Bamberg, F.* ; Nikolaou, K.* ; Bohla, A. ; Yildirim, A.Ö. ; Loewen, R.* ; Gifford, M.* ; Ruth, R.* ; Eickelberg, O. ; Reiser, M.* ; Pfeiffer, F.*

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source.

Proc. Natl. Acad. Sci. U.S.A. 109, 17880-17885 (2012)
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In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Grating Interferometer ; Pulmonary Emphysema ; X-ray Imaging; Phase-contrast Images ; Grating Interferometer ; Talbot Interferometry ; Computed-tomography ; Lung-tissue ; Copd ; Radiography ; Visualization ; Speckle ; Origin
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 109, Issue: 44, Pages: 17880-17885 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-001
G-505000-007
PubMed ID 23074250
DOI 10.1073/pnas.1206684109
WOS ID WOS:000311149900046
Scopus ID 84868152432
Erfassungsdatum 2012-12-06
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